Close this search box.

Discover How Personalized Immunotherapy is Transforming Advanced Cancer Treatment: Real Patient Success Stories

The battle against cancer has seen many innovative therapies, but personalized immunotherapy stands out for its potential to revolutionize treatment. Between 2001 and 2014, Dr. John Catanzaro’s clinic administered the Generation 1 Personalized Edited Sequence (G1-PES) vaccine to 43 patients with severe metastatic cancer, marking a significant advancement in cancer treatment.

Understanding G1-PES

The G1-PES vaccine is a form of immunopeptide therapy, designed to target tumor neoantigens and harness the body’s T cell-mediated immune response. This personalized approach aims to achieve remission and cancer-free survival within 18 months, a goal previously considered unattainable for terminal-stage cancer patients.

Study Overview

Patients enrolled in the G1-PES therapy program were given an 18-month treatment, consisting of four cycles every 12 weeks. These patients were initially considered for only 3 to 4 months of life support with no hope for recovery. The study assessed the vaccine’s safety and efficacy through adverse events, progression-free survival (PFS), and overall survival (OS).


The G1-PES vaccine proved to be both safe and effective. No serious adverse effects (SAEs) were reported. Minor reactions, such as slight fever, flu-like symptoms, and rash at the injection site, were self-limiting and resolved within days. Remarkably, patients experienced significant improvements in their quality of life within 1-3 weeks of starting therapy. Clinical evidence showed notable cancer regression (p<0.001).

The results were particularly impressive:

  • Tumor Regression: Patients showed an average tumor regression of 58.37% ± 32.25%.
  • Extended Survival: The average extended survival was recorded at 5.78 ± 2.7 years.
  • Quality of Life: Patients reported an average score of 7.3 ± 2.5 on a 10-point quality of life scale.

Efficacy Across Cancer Types

The G1-PES vaccine demonstrated broad anti-tumor efficacy across various types of advanced metastatic cancer:

  • Lymphoma: 90.0 ± 14.1% tumor regression.
  • Prostate Cancer: 80.0 ± 28.3% tumor regression.
  • Malignant Melanoma and Breast Cancer: Moderate tumor regression response.
  • Non-Small Cell Lung Carcinoma and Colon Cancer: Statistically significant tumor regression.

Mechanism of Action

The G1-PES vaccine works by targeting tumor neoantigens, which directs the immune response specifically towards cancer cells, thereby minimizing the risk of autoimmune reactions. This precision targeting makes it a potent and versatile treatment option.


The study directly demonstrates the ability of the G1-PES vaccine to safely and effectively target various types of cancer. Over 500 patients received this personalized therapy, with no serious adverse events, highlighting its safety and efficacy. The Health and Wellness Institute Integrative Cancer Treatment (HWIIC) and Cancer Research Group in Seattle administered these individualized immunopeptides as an adjunctive treatment, showing significant improvement in patients’ quality of life and clinical outcomes.


The G1-PES vaccine represents a groundbreaking approach in cancer immunotherapy, offering hope to patients with advanced metastatic cancer. The study underscores its potential to improve quality of life, extend survival, and achieve significant tumor regression. As personalized immunotherapy continues to evolve, the G1-PES vaccine stands out as a beacon of innovation and hope in the fight against cancer.

Key Takeaways:

  • Personalized Immunotherapy: G1-PES targets tumor neoantigens, leveraging the body’s immune response.
  • Safety: No serious adverse effects; minor reactions were self-limiting.
  • Efficacy: Significant tumor regression and extended survival rates across various cancer types.
  • Quality of Life: Markedly improved within weeks of starting therapy.

This innovative treatment showcases the transformative potential of personalized cancer immunotherapy, paving the way for more effective and targeted cancer treatments in the future.

Ready to Schedule Your Free 15 Minute Discover Call?

At The Karlfeldt Center, we are proud to offer the G1-PES vaccine as part of our comprehensive cancer treatment program. If you or a loved one are battling advanced metastatic cancer, contact us today at 208-338-8902 to learn more about how this groundbreaking therapy can provide hope and improve quality of life. Your journey to better health starts here.

Our dedicated team will promptly reach out to discuss your options. Contact us today to learn more about how  The Karlfeldt Center’s Integrative Oncology Program can help guide you through your cancer journey toward renewed health and vitality.

You might also be interested in...